There was thus uncertainty regarding the optimal frequency of pulses in COG ALL therapy.
showed that pulses of vincristine and dexamethasone during the continuation phase of BFM treatment do not affect overall survival in children with intermediate-risk ALL. Plenary Paper # 2001|||REDUCED FREQUENCY OF MAINTENANCE PULSES IN STANDARD-RISK B ACUTE LYMPHOBLASTIC LEUKEMIA AALL0932Īnne Angiolillo, Reuven Schore, John Kairalla, Meenakshi Devidas, Karen Rabin, Patrick Zweidler-McKay, Michael Borowitz, Brent Wood, Andrew Carroll, Nyla Heerema, Mary Relling, Ashley Lane, Kelly Maloney, Cindy Wang, William Carroll, Naomi Winick, Raetz Raetz, Mignon Loh, Stephen HungerĬhildren's National Medical Center, Washington, District of Columbia, United Statesīackground: A key component of COG maintenance chemotherapy for B-ALL has been vincristine/steroid pulses administered every 4 weeks.
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